Guide to Sucralose

Sucralose is a commonly used artificial food sweetener that provides no nutrition. It’s about 600 times as sweet as table sugar and the majority of it is not absorbed by the body. It has been licensed for use as a sweetener in the EU since 2004 as E number E955.

Sucralose is a trichlorinated sucrose molecule; i.e. it’s a form of sucrose (table sugar) that’s been altered chemically. Sucralose is very stable: it’s not affected by heat or light and is unaffected by a broad range of pH conditions. As well as its reliable stability, sucralose is also favored in respect of taste and texture and it has no negative after-taste; therefore, sucralose is a great choice both for baking and for commercial products that require a longer shelf life.

As well as the EU, sucralose is licensed for use in the USA, Australia, and Canada; in fact over 80 countries in total. Indeed, it is experiencing increasing popularity as a sweetener when compared to other commonly used artificial sweeteners like aspartame, acesulfame K and saccharin.

What happens to Sucralose after consumption?

After consuming sucralose, the majority of it is not absorbed into the body and passes through the digestive system to be excreted in feces. As sucralose is poorly absorbed by the digestive tract, only 5 to 20% of it actually enters the blood. The remainder is removed through urine, essentially unchanged and none is stored in tissues^[1]. Therefore, sucralose is actually only present in the body for a short time after consumption.

Health benefits of Sucralose

Although sucralose has no actual direct health benefits, as it’s a nonnutritive alternative to sugar, it has a number of indirect benefits associated with this use. The consumption of sugar is well known to be associated with dental caries (tooth decay) and periodontal (gum) disease. Using sucralose reduces sugar intake with the consequential benefits to dental health and it has thus been shown to be non-cariogenic^[2].

Sucralose, being a nonnutritive sweetener, is used in many low-calorie products. It therefore has favorable applications for people trying to lose weight and subsequent beneficial effects on diseases associated with obesity including cardiovascular disease (CVD), type 2 diabetes, polycystic ovarian syndrome and some cancers^[3]. It’s been shown to have no effect on hunger signaling and does not initiate an insulin response^[4].

As well as contributing to obesity, sugar consumption has also been identified as a risk factor for CVD through its effects on serum triglycerides (a risk factor for CVD). Therefore consuming sucralose in place of sugar has positive implications in the reduction of risk of heart disease, stroke, and peripheral vascular disease.

Sucralose is also a suitable sweetener for sugar-free products suitable for use by both type 1 and type 2 diabetics as it has no effect on blood glucose or serum insulin levels^{[3, 4]}.

Health concerns of Sucralose

Some people claim that sucralose alters the amount and quality of the good bacteria that reside symbiotically in our gut. This claim was mostly based around a 2008 study by Abou-Donia et al^[5]. It’s also been claimed that sucralose limits the absorption of some therapeutic drugs rendering them less effective^{[5, 6]}. There are further suggestions that sucralose decomposes during baking and releases potentially toxic compounds called chloropropanols^[6].

However, the Abou-Donia et al paper has been debunked by many including an Expert Panel who found that the study was deficient in several critical areas and stated that its results could be interpreted as implicative that there are any problems with sucralose ingestion^[7]. The Abou-Donia et al study and the Schiffman & Rother (2013) review - and it should be noted that both these papers were published in the same journal - based their findings on rats, not humans, and these rats were fed large amounts based on their body weight^{[5, 6]}. Indeed, they were actually fed the brand of sucralose Splenda which contains maltodextrin and dextrose as fillers alongside sucralose, so any ill effect could have been due to these high glycaemic index carbohydrates and not the sucralose. Other studies have indicated that there is no change in gut function including to gut microflora following sucralose consumption^{[7, 8]}.

There have been more recent studies that have looked at the effect of sucralose on the gut microbiota^[8-10]. At levels equal to the US ADI, 5mg per kilogram of body weight per day (5mg/kg bw/day) it appears sucralose has an inhibitory effect on isolated E.coli bacteria in a lab^[9]. In mice it has also been shown by Bian et al. that the same levels can increase the expression of bacterial pro-inflammatory genes and disrupt fecal metabolites^[10]. However, the dose was given all in one sitting, which is not representative of how sucralose is normally consumed, at much lower levels throughout the day. When looking at 11.25mg/kg bw/day, over twice the US ADI, in humans it appears sucralose has no effect on the gut microbiome^[8]. It maybe that sucralose has a negative effect on the gut microbiome, however the current evidence is weak and not present in the limited number of human studies. Furthermore, such studies have not looked at the impact when ingested with other compounds such as prebiotic fibres which may negate any minimal effect sucralose may have.

One other claim - a claim that is also made about some other non-caloric sweeteners - is that there is an altered insulin response, blood sugar level and, in turn, appetite following consumption of sucralose. There are claims that this is a learned sensory response from associating the sweet taste of sucralose with sugar which leads to the insulin response^[6]. It’s well known that high sugar intakes only lead to short term satiety and this is followed by a subsequent increase in appetite and it has been claimed that the same happens following sucralose ingestion. However, this is not the case and the sensation of appetite is very complex involving a number of hormones as well as there being sensory involvement via the nervous system^[11,12]. Indeed, it’s been demonstrated that sucralose has no effect on a person’s blood glucose response or appetite when studied up to 12 weeks^[3,8,11,12].

There have also been articles claiming a link between high sucralose intakes with diabetes and heart disease. However, when we look at data we need to be careful, as it may be simply a case of food choice that’s the issue rather than the sweetener itself; for example, people with poor diet choices may be more likely to include artificially sweetened beverages in their diet: this merely demonstrates association and not causality.

There have been some articles claiming an association between sucralose and tumor development, some of which reference the Ramazzini Institute study^[13]. There are a number of issues with this study. Firstly, as in the case of the Abou-Donia et al study, this trial was performed on rodents (mice) and not humans: whilst trials on rodents can be useful, they are often quite poor at predicting how humans will react^[14].

The second issue refers to the high levels of sucralose that the mice were fed. The US FDA recommends that humans do not consume more than 5mg of sucralose per kilogram body weight^[15]. The mice receiving the smallest dose of sucralose received 12 times the US AD: 60mg of sucralose per kg bodyweight. At very high doses most substances are likely to have a negative effect on your body; even water, for example: consuming 12 times the recommended amount can give rise to water intoxication, with serious adverse reactions; this does not mean clean water is in any way dangerous at typical intakes. At the time of writing, no study has found any negative effects from using sucralose when consumed within recommended amounts. There have been well over 100 studies published in peer reviewed articles, some demonstrating that there was no link with tumors in rats at all^{[2, 16]}.

Furthermore, whilst the study highlighted that there was a rise in tumor incidence for male mice, female mice actually saw a reduction in cancer. When male and female mice cancer rates are included together, there is essentially no change in the cancer rate at any dosage. Splenda was also fed to the mice throughout their life, including in utero; there may be a specific period during a male mice’s life that causes issues from sucralose consumption at this dose. A more recent review of 56 studies concluded that non nutritive sweeteners have no effect on cancer risk^[17].

Is Sucralose safe?

Sucralose has been demonstrated to be safe for consumption by humans by numerous studies and reports. The adverse press sucralose receives seems primarily to be due to the fact that it is artificial and this term is very much maligned in nutrition. It’s important to note that ‘artificial’ doesn’t always mean bad in the same way as ‘natural’ doesn’t always mean good. A quick internet search will reveal a number of articles and blog posts demonizing sucralose and reporting it in a negative manner. These are really only based on poorly designed studies and other articles - most of which have subsequently been discredited - or the fact that naturalistic advocators feel that, because sucralose is artificial, it isn’t good for the body and should be avoided. Too often people latch onto a study and take its results as given ignoring the study design and conflicting factors. The sucralose debate is a clear demonstration of this.

It’s been concluded that sucralose is safe and its use is permitted in most countries.

The EU safe level of sucralose is 15mg per kg body weight per day^[18]. This safe level has been made up with caution in mind and no effects have been reported in levels as much as 1,500mg/kg/day^[4]. However, the acceptable daily intake (ADI) in Canada has been set at a recommended 9mg/kg/day^[19] and the US ADI is 5mg/kg/day^[15].

Sucralose in Huel

The flavored Huel Powders (v3.0) and Huel Ready-to-drink contain a small amount of sucralose: it’s what we feel is just enough to contribute to that particular flavor. We offer an Unflavored & Unsweetened version of Huel Powder v3.0 which contains no sucralose or any other sweetener.

Huel Black Edition is a flavored powder (vanilla or chocolate) that is sweetened by stevia and a small amount of organic coconut sugar. We’ve listened to Hueligans which is why we’ve worked hard to develop a flavored Huel Powder that tastes great with no sucralose. 

Choosing a sweetener

There are a large number of other sweeteners permitted in foods. Other artificial sweeteners like aspartame, acesulfame K and saccharin, have no advantages over sucralose. In fact, the taste of sucralose is generally preferred and none of these are without their own health concerns.

The taste of sucralose is also why it is used in Huel Powder v3.0. If stevia was used as the sole sweetener then levels would be reaching the limits imposed by government regulations. Additionally, some people, due to genetics, report that they detect a bitter and unfavorable aftertaste when stevia is used in too high amounts^[20]. By offering Huel Powder v3.0 and Black Edition with different macronutrient profiles and sweetener systems there is a product to suit individual tastes and preferences.

References

1. Sims J, et al. The metabolic fate of sucralose in rats. Food Chem Toxicol. 2000;38(2):115-21.
2. EFSA Panel on Dietetic Products N, et al. Scientific Opinion on the substantiation of health claims related to the sugar replacers xylitol, sorbitol, mannitol, maltitol, lactitol, isomalt, erythritol, D-tagatose, isomaltulose, sucralose and polydextrose and maintenance of tooth mineralisation by decreasing tooth demineralisation (ID 463, 464, 563, 618, 647, 1182, 1591, 2907, 2921, 4300), and reduction of post-prandial glycaemic responses (ID 617, 619, 669, 1590, 1762, 2903, 2908, 2920) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA Journal. 2011; 9(4):2076.
3. Brown AW, et al. Short-term consumption of sucralose, a nonnutritive sweetener, is similar to water with regard to select markers of hunger signaling and short-term glucose homeostasis in women. Nutr Res. 2011;31(12):882-8.
4. Baird IM, et al. Repeated dose study of sucralose tolerance in human subjects. Food Chem Toxicol. 2000;38(2):123–9.
5. Abou-Donia MB, et al. Splenda alters gut microflora and increases intestinal p-glycoprotein and cytochrome p-450 in male rats. J Tox Environ Health. 2008;71(21):1415-29.
6. Schiffman SS, Rother KI. Sucralose, A Synthetic Organochlorine Sweetener: Overview of Biological Issues. J Toxicol Environ Health B. 2013;16(7):399–451.
7. Brusick D, et al. Expert panel report on a study of Splenda in male rats. Reg Toxicol Pharm. 2009;55(1):6-12.
8. Thomson P, et al. Short-term impact of sucralose consumption on the metabolic response and gut microbiome of healthy adults. British Journal of Nutrition. 2019; 122(8):856-62.
9. Harpaz D, et al. Measuring Artificial Sweeteners Toxicity Using a Bioluminescent Bacterial Panel. Molecules. 2018; 23(10):2454.
10. Bian X, et al. Gut Microbiome Response to Sucralose and Its Potential Role in Inducing Liver Inflammation in Mice. Frontiers in physiology. 2017; 8:487-.
11. Jing Ma, et al. Effect of the artificial sweetener, sucralose, on gastric emptying and incretin hormone release in healthy subjects. Am J Physiol. 2009;296(4):735-739.
12. Ford HE, et al. Effects of oral ingestion of sucralose on gut hormone response and appetite in healthy normal-weight subjects. Eur J Clin Nutr. 2011;65:508–513.
13. Soffritti M et al. The Ramazzini Institute: Sucralose administered in feed, beginning prenatally through lifespan, induces hematopoietic neoplasias in male swiss mice. Int J Occ & Environ Health. 2016; 22(1).
14. Bracken MB. Why animal studies are often poor predictors of human reactions to exposure. Journal of the Royal Society of Medicine. 2009; 102(3):120-2.
15. FDA. Food Substances for Direct Addition to Food for Human Consumption. 2018; 21(3).
16. Mann SW, et al. A combined chronic toxicity/carcinogenicity study of sucralose in Sprague-Dawley rats.Food Chem Toxicol. 2000;38(2):71-89.
17. Toews I, et al. Association between intake of non-sugar sweeteners and health outcomes: systematic review and meta-analyses of randomised and non-randomised controlled trials and observational studies. BMJ. 2019; 364:k4718.
18. European Commission. Opinion of the Scientific Committee on Food on sucralose. 2000.
19. Diabetes Canada. Sugars and Sweeteners. 2018. Available from: https://guidelines.diabetes.ca/docs/patient-resources/sugars-and-sweeteners.pdf
20. Risso D, et al. Genetic signature of differential sensitivity to stevioside in the Italian population. Genes Nutr. 2014; 9(3):401-.
21. Risso D, et al. Genetic signature of differential sensitivity to stevioside in the Italian population. Genes Nutr. 2014; 9(3):401-.